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what causes kidney stones?

Kidney stones are formed due to a combination of various factors, including dietary habits, medical conditions, and lifestyle choices. Here are the key causes and risk factors:

Low Fluid Intake

One of the most significant risk factors for developing kidney stones is not drinking enough fluids. Low urine volume concentrates the minerals in the urine, making it more likely for them to crystallize and form stones134.

Dietary Factors

  • High-Sodium Diet: Consuming high amounts of sodium can increase the levels of calcium in the urine, leading to the formation of calcium stones. Foods high in salt, such as canned foods, prepackaged meals, and table salt, contribute to this risk124.
  • Animal Proteins: A diet rich in animal proteins (e.g., chicken, beef, pork, fish) can increase the risk of uric acid stones due to the high levels of purines in these foods25.
  • Oxalate and Calcium Balance: While calcium itself does not cause kidney stones, a low-calcium diet can lead to higher oxalate levels in the urine, increasing the risk of calcium oxalate stones. Conversely, adequate calcium intake can help bind oxalate in the gut and reduce its absorption into the bloodstream and subsequently into the urine245.
  • High Fructose Intake: Consuming foods with high fructose corn syrup can increase the risk of kidney stones, particularly uric acid stones4.

Medical Conditions

  • Hyperparathyroidism: This condition causes the body to pull too much calcium from the bones, leading to high calcium levels in the blood and urine1.
  • Cystinuria: An inherited genetic disorder that causes cystine to leak into the urine, leading to cystine stones15.
  • Hyperoxaluria: A condition where the liver produces too much oxalate, increasing the risk of oxalate stones1.
  • Hypercalciuria: High levels of calcium in the urine, which can be due to genetic predisposition, high sodium intake, or certain medications15.
  • Urinary Tract Infections: These can lead to the formation of struvite stones135.

Other Risk Factors

  • Family History: A family history of kidney stones increases the risk, possibly due to genetic factors or similar dietary habits135.
  • Obesity and Sedentary Lifestyle: Being overweight or inactive can increase the risk of developing kidney stones34.
  • Certain Medications: Medications such as diuretics, antacids, certain antibiotics, and antiretroviral medicines can increase the risk of kidney stones35.
  • Bowel or Gastrointestinal Conditions: Conditions like Crohn’s disease, ulcerative colitis, or gastric bypass surgery can affect fluid and mineral balance, increasing the risk of kidney stones14.

Additional Factors

  • Infections: Recurrent urinary tract infections can lead to struvite stones135.
  • Gout and Diabetes: These conditions can also increase the risk of developing kidney stones, particularly uric acid stones5.

Understanding these causes and risk factors can help in preventing and managing kidney stone formation.

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