How did Matthew Perry die?

Matthew Perry, the actor known for his role as Chandler Bing in the TV show "Friends," died due to a combination of factors, primarily related to the effects of ketamine.

Here are the key details from the autopsy report and subsequent investigations:

• Perry died on October 28, 2023, at the age of 54, after being found unresponsive in his jacuzzi at his Los Angeles home123.
• The autopsy report concluded that his death was caused by the acute effects of ketamine, a drug he had been using as part of an experimental treatment for depression and anxiety. The levels of ketamine in his system were high enough to cause loss of consciousness, respiratory depression, and increased heart rate and blood pressure123.
• Drowning was listed as a secondary factor in his death, as he was found face down in the water. However, the primary cause was the effects of the ketamine123.
• Other contributing factors included coronary artery disease and the presence of buprenorphine, a medication used to treat opioid use disorder, which can also depress breathing when combined with ketamine123.

The method of ketamine intake at the time of his death was listed as unknown, but it was noted that the levels in his system could not have resulted from his last known ketamine infusion therapy, which was 1 1/2 weeks before his death123.